4.8 Article

Concise Synthesis of Pauciflorol F Using a Larock Annulation

Journal

ORGANIC LETTERS
Volume 11, Issue 23, Pages 5450-5453

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902141z

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Funding

  1. UC Berkeley
  2. NIH [RO1 GM84906-01]
  3. American Cancer Society [RSG-09-017-01-CDD]
  4. NSF
  5. Alfred P. Sloan Foundation
  6. Camille Dreyfus Teacher-Scholar

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A Pd-catalyzed Larock annulation provides expedient access to a subset of resveratrol-derived natural products. The reported approach resulted in the structural revision of an intermediate en route to the natural product pauciflorol F, the total synthesis of which proceeded in two steps from the requisite pentannulation product.

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