Journal
ORGANIC LETTERS
Volume 11, Issue 16, Pages 3602-3605Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901350g
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Funding
- Japan Science and Technology Agency (JST)
- Grants-in-Aid for Scientific Research [21370051] Funding Source: KAKEN
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Resolvin E2 is a potent anti-inflammatory compound, derived from eicosapentaenoic acid. The efficient total synthesis of resolvin E2 by taking advantage of its intrinsic pseudoenantiomeric substructures is reported. The synthetic resolvin E2 proved to be biologically active in blocking neutrophil Infiltration and reducing proinflammatory cytokines in the acute peritonitis model.
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