Journal
ORGANIC LETTERS
Volume 11, Issue 17, Pages 3990-3993Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901655e
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- National Institute of General Medical Sciences [GM60567]
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The total synthesis of (+)-iriciniastatin A (psymberin) is reported in 19 steps and 6% overall yield. Key reactions include a highly convergent enolsilane-oxocarbenium Ion union to generate the C8-C25 fragment and a late-stage coupling of a hemiaminal and acid chloride to complete the synthesis.
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