4.8 Article

Palladium-Catalyzed Cyclization of Unsaturated β-Amino Alcohols: A New Access to Enantiopure Bicyclic Oxazolidines

Journal

ORGANIC LETTERS
Volume 11, Issue 16, Pages 3746-3749

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901375w

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Funding

  1. Universitd Pierre et Marie Curie-Paris 6 [7201]

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Chiral unsaturated beta-amino alcohols possessing a dialkylamino function cyclize in the presence of Pd(II) catalysts and reoxidants to afford enantiopure bicyclic oxazolidines with total regio- and stereocontrol. The scope and limitations of this transformation have been studied.

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