Journal
ORGANIC LETTERS
Volume 11, Issue 16, Pages 3582-3585Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901305q
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Funding
- National Natural Science Foundation of China [20672136, 20702060, 20832006)]
- Shanghai Municipal Committee of Science and Technology [07XD14038]
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With the catalysis of palladium, a number of 2-bromo-N-(2-iodobenzyl)benzamides underwent sequential cyanation/N-addition/N-arylation leading to the efficient construction of isoindolo[1,2-b]quinazolin-10(12H)-ones in a two-stage, one-pot manner. This method also allowed the convenient synthesis of luotonin A and its derivatives.
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