Journal
ORGANIC LETTERS
Volume 11, Issue 18, Pages 4040-4043Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9013602
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Funding
- Enterprise Ireland
- IRCSET
- HEA-PRTLI Cycle 3 and Cycle 4 (CSCB)
- TCD
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The synthesis and photophysical and biological Investigation of fluorescent 1,8-naphthalimide conjugated Troger's bases 1-3 are described. These structures bind strongly to DNA in competitive media at pH 7.4, with concomitant modulation in their fluorescence emission. These structures also undergo rapid cellular uptake, being localized within the nucleus within a few hours, and are cytotoxic against HL60 and (chronic myeloid leukemia) K562 cell lines.
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