Journal
ORGANIC LETTERS
Volume 11, Issue 15, Pages 3354-3356Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901204b
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Funding
- Robert A. Welch Foundation [T-1460]
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A new pyrrolidine-based organocatalyst for asymmetric reactions has been developed and shown to be a very effective catalyst for the Michael reaction involving various nitroolefins and aldehydes in water. This design is based on the introduction of a hydrophilic group into the pyrrolidine side chain. This catalyst, di(methylimidazole)prolinol silyl ether in combination with sodium bicarbonate as additive effectively catalyzed the Michael addition of aldehydes to nitroolefins In water as solvent in high yields and excellent enantioselectivities.
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