Journal
ORGANIC LETTERS
Volume 11, Issue 14, Pages 3008-3011Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9010344
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Funding
- Ministry of Education [R143-000-390-315]
- Agency for Science, Technology and Research (A*Star) of Singapore [R154-000-274-305]
- National Research Foundation [R143-000-218-281]
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A panel of new fluorophores with emission wavelengths from blue to yellow regions using the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of alkyne-functionalized xanthones and xanthenes with various azides have been synthesized. Screening of the click products led to the identification of hit fluorophores which showed a fluorescence increase upon triazole formation. These novel click fluorophores could potentially be used for bioconjugation and bioimaging purposes.
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