Journal
ORGANIC LETTERS
Volume 11, Issue 16, Pages 3690-3693Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901525t
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Funding
- CNRS
- interregional CRUNCH network, INSA
- University of Rouen
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The first palladium-catalyzed borylation of 4-bromo-2-ketothiazoles followed by a Suzuki cross-coupling reaction with haloheteroaromatics using Buchwaid's Cy-JohnPhos and XPhos ligands is reported. The methodology has allowed the fast preparation of highly valuable 4-pyridinyl- and 4-thiazolyl-2-ketothiazoles as common subunits of thiopeptide antibiotics. As direct applications, novel concise syntheses of a sulfomycinamate thio-analogue as well as micrococcinate and saramycetate esters are described.
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