Journal
ORGANIC LETTERS
Volume 11, Issue 6, Pages 1401-1404Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9000813
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Funding
- National Natural Science Foundation of China [20732003, 20872096]
- Ministry of Education [20070610019]
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The N,N'-dioxide-Sc(III) complex has been applied in the three-component Kabachnik-Fields reaction of aldehydes, 2-aminophenol, and diphenyl phosphite, giving the corresponding alpha-amino phosphonates in good yields with high enantioselectivities (up to 87% ee). The direct Kabachnik-Fields reaction proceeded with extremely high reactivity under mild reaction conditions and could be used for large-scale synthesis of the cc-amino phosphonates.
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