4.8 Article

A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis

Journal

ORGANIC LETTERS
Volume 11, Issue 4, Pages 999-1002

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol8029593

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Funding

  1. Danish National Research Foundation
  2. Carlsberg Foundation
  3. OChem
  4. iNANO Graduate Schools
  5. University of Aarhus

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Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of beta-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and F-19-BAY94-9172.

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