Journal
ORGANIC LETTERS
Volume 11, Issue 9, Pages 1935-1938Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol900366m
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- Leverhulme Trust
- EPSRC
- AstraZeneca
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Catalytic asymmetric deprotonation-aldehyde trapping-ring expansion from a 5- to a 6-ring delivers a concise route to each stereoisomer of beta-hydroxy piperidines starting from N-Boc pyrrolidine. The methodology is utilized in a 5-step catalytic asymmetric synthesis of the neorokinin-1 receptor antagonist, (+)-L-733,060.
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