Journal
ORGANIC LETTERS
Volume 11, Issue 22, Pages 5330-5333Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902173g
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- National Institutes of Health
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Synthesis of an advanced welwitindolinone intermediate via an alkylation/cyclization reaction Is reported. The key step involves a one pot Lewis acid-mediated alkylation of a silylketene aminal with a furan alcohol followed by an intramolecular cyclization. The reaction is stereoselective and takes place at low temperature. The cycloadduct was highly functionalized and contains the welwitindolinone core structure.
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