4.8 Article

Asymmetric Construction of Rings A-D of Daphnicyclidin-Type Alkaloids

Journal

ORGANIC LETTERS
Volume 11, Issue 24, Pages 5658-5661

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902373m

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Funding

  1. NTH Neurological Disorders & Stroke Institute [NS-12389]
  2. Alexander von Humboldt Foundation [HL078104, GM-082113]
  3. NSF

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The aza-Cope-Mannich reaction and ring-closing metathesis are key steps in the assembly of intermediates containing rings A-D of Daphniphyllum alkaloids of the daphnicyclidin type such as daphnipaxinin and oldhamine A.

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