Journal
ORGANIC LETTERS
Volume 11, Issue 13, Pages 2828-2831Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol900997t
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- NIH [GM075885]
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A series of novel sterol analogs was prepared using nitroso Diels-Alder reactions with ergosterol. Most cycloaddition reactions proceeded in an excellent regio- and stereoselective fashion. Further N-O bond cleavage of cycloadducts generated compounds with biological activity in PC-3 and MCF-7 cancer cell lines.
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