Journal
ORGANIC LETTERS
Volume 11, Issue 2, Pages 305-308Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol802464g
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Funding
- NSF [CHE-0616840]
- Nebraska Center for Energy Sciences Research and Nebraska UCARE
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0911732] Funding Source: National Science Foundation
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The use of NADH- and NADPH-dependent ketoreductases to access enantioenriched pharmaceutical building blocks is reported. Seven structurally diverse synthons are obtained, including those for atomoxetine (KRED 132), talampanel (RS1-ADH and CPADH), Dolastatin (KRED 132), and fluoxetine (KRED 108/132). Ethanol may be used as stoichiometric reductant, regenerating both nicotinamide cofactors, particularly under four-electron redox conditions. Its favorable thermodynamic and economic profile, coupled with its advantageous dual cosolvent role, suggests a new application for biomass-derived ethanol.
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