Journal
ORGANIC LETTERS
Volume 11, Issue 16, Pages 3678-3681Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901511x
Keywords
-
Categories
Funding
- MOST [2010CB833200]
- NSFC [20672128]
- CAS [KJCX2-YW-H08]
- Shanghai Municipal Committee of Science and Technology [07DZ22001]
Ask authors/readers for more resources
A straightforward synthesis of 4-amido-N-6-acetyl-4-deoxyneuraminic acid, a key precursor to various 4-amidoneuraminic acid analogues, has been achieved using a highly regioselective and diastereoselective [3 + 2]-cycloaddition of D-mannose-derived nitrone with methyl acrylate. Advantages of this newly developed synthesis include the use of economically available materials and reagents, the ease of operations and the excellent control of stereochemistry, as well as the convenience in application to the C-4 modifications of sialic acids.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available