4.8 Article

Direct Synthesis of Medium-Bridged Twisted Amides via a Transannular Cyclization Strategy

Journal

ORGANIC LETTERS
Volume 11, Issue 17, Pages 3878-3881

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901449y

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Funding

  1. National Institute of General Medical Sciences [GM-49093]

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The sequential RCM to construct a challenging medium-sized ring followed by a transannular cyclization across a medium-sized ring delivers previously unattainable twisted amides from simple acyclic precursors.

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