Journal
ORGANIC LETTERS
Volume 11, Issue 23, Pages 5406-5409Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9022672
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Funding
- Canada Research Chair Program
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
- Merck Frosst Centre for therapeutic Research
- Fonds de recherche sur la nature et les technologies
- Universite Laval
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A simple and effective method for stereocontrolled preparation of 1,1-diaryl-2-fluoroethenes is reported. First, 1-aryl-1-bromo-2-fluoroethenes are generated using an addition/elimination reaction of hydride to silylated beta,beta-difluorostyrene derivatives followed by a bromination/desilicobromination reaction. Subsequent Suzuki-Miyaura coupling with a variety of boronic acids gives access to the desired 1,1-diaryl-2-fluoroethenes.
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