Journal
ORGANIC LETTERS
Volume 11, Issue 21, Pages 5062-5065Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9020546
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Suntory Institute for Bioorganic Research
- Naito Foundation
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A novel cytotoxic peptide, termed bisebromoamide (1), has been isolated from the marine cyanobacterium Lyngbya sp. Its planar structure was determined by 1D and 2D NMR spectroscopy. The absolute stereostructure of 1 was determined by chemical degradation followed by chiral HPLC analysis. Bisebromoamide (1) exhibited potent protein kinase inhibition: the phosphorylation of ERK in NRK cells by PDGF-stimulation was selectively inhibited by treatment with 10-0.1 mu M of 1.
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