Journal
ORGANIC LETTERS
Volume 11, Issue 23, Pages 5366-5369Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9018584
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Funding
- National Science Foundation [NSF-CHE-0709061]
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Lewis acid complexation is generally required for chiral-auxiliary-controlled stereoselectivity, and chiral Lewis acid catalysis is frequently optimal for introducing asymmetry. In this work, we show that nitrile ylide cycloadditions to electron-poor acceptors attached to chiral auxiliaries proceed in high yield and stereoselectivity In the absence of Lewis acids. In contrast, chiral Lewis acids are inferior in these cycloadditions.
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