Journal
ORGANIC LETTERS
Volume 11, Issue 3, Pages 593-596Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8027253
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Funding
- NIH [GM28961]
- Intramural Research Program
- CCR
- NCI
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A close structural analogue of bryostatin 1, which differs from bryostatin 1 only by the absence of the C-30 carbomethoxy group (on the C-13 enoate of the B-ring), has been prepared by total synthesis. Biological assays reveal a crucial role for substitution in the bryostatin 1 A-ring in conferring those responses which are characteristic of bryostatin 1 and distinct from those observed with PMA.
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