Journal
ORGANIC LETTERS
Volume 11, Issue 18, Pages 4156-4159Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901684h
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- Ministry of Education, Culture, Sports, Science, and Technology, Japan
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The direct C-H alkynylation of azoles with alkynyl bromides proceeds efficiently in the presence of a nickel-based catalyst system. The reaction enables the introduction of various alkynyl groups bearing aryl, alkenyl, alkyl, and silyl substituents to the azole cores. In some cases, addition of a catalytic amount of CuI is observed to accelerate the direct coupling dramatically.
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