Journal
ORGANIC LETTERS
Volume 11, Issue 23, Pages 5370-5373Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901999f
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Funding
- Department of Defense PCRP Concept [W81XWH04-1-0647]
- PCRP Training Award [W81XWH09-1-0208]
- National Institutes of Health [5R37 DK015556]
- NRSA [1 F30 ES016484-01, 5 T32 GM070421]
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A novel series of biphenyl proteomimetic compounds were designed as estrogen receptor-alpha (ER alpha) coactivator binding Inhibitors. Synthesis was accomplished through a convergent approach, employing Suzuki coupling chemistry to ligate the Individual modular units. Initial biological results support the ability of these compounds to compete for the ER alpha coactivator binding groove.
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