4.8 Article

Synthetic Method for the Preparation of 2-Aminomethyl-1,3-diene Derivatives through Indium-Mediated 1,3-Butadien-2-ylation of Imines

Journal

ORGANIC LETTERS
Volume 11, Issue 11, Pages 2401-2404

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol9005213

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Funding

  1. Korea Science and Engineering Foundation (KOSEF) [M10600000203-06J0000-20310]
  2. Korean Government (MOEHRD) [KRF-2006-353-C00030]
  3. Korea Sanhak Foundation
  4. BK21 program

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An efficient method for the preparation of a variety of 2-aminomethyl-1,3-dienes was developed through the reaction of imines with organoindium reagent generated in situ from indium and 1,3-dibromo-2-butyne. Three-component reactions of aldehydes, amines, and organoindium reagents gave successful results in a one-pot process.

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