4.8 Article

Benzyne click chemistry: Synthesis of benzotriazoles from benzynes and azides

Journal

ORGANIC LETTERS
Volume 10, Issue 12, Pages 2409-2412

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol800675u

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Funding

  1. NIGMS NIH HHS [GM 070620, R01 GM070620, GM 079593, P50 GM 069663, P50 GM069663, P41 GM079593] Funding Source: Medline

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A variety of substituted, benzotriazoles have been prepared by the [3 + 2] cycloaddition of azides to benzynes. The reaction scope is quite general, affording a, rapid and easy entry to substituted, functionalized benzotriazoles under mild conditions.

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