Journal
ORGANIC LETTERS
Volume 10, Issue 17, Pages 3915-3918Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8015012
Keywords
-
Categories
Ask authors/readers for more resources
A procedure for nucleophilic addition of diethylzinc to trifluoromethyl ketones was developed. The TMEDA-catalyzed method converts aromatic substrates to the corresponding 2-aryl-1,1,1-trifluorobutan-2-ols in up to 99% yield, and it is also applicable to less reactive aliphatic ketones if stoichiometric ligand amounts are employed. The first asymmetric variant producing tertiary alcohols with up to 61% ee when TBOX is used as catalyst is described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available