4.8 Article

The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000

Journal

ORGANIC LETTERS
Volume 10, Issue 20, Pages 4641-4644

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol8019555

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Funding

  1. Science Foundation Ireland

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The first total synthesis of a thioglycoside analogue of KRN7000, a potential immunostimulant, is described. Two key intermediates are alpha-galactosyl thiol 4 and phytosphingosine derivative 5, which were both prepared from D-galactose.

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