4.8 Article

A Phosphine-Catalyzed [3+2] Annulation Reaction of Modified Allylic Compounds and N-Tosylimines

Journal

ORGANIC LETTERS
Volume 10, Issue 20, Pages 4481-4484

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol801661y

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Funding

  1. National Natural Science Foundation of China [20572121]
  2. Chinese Academy of Sciences

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A phosphine-catalyzed annulation of modified allylic ylides with various aromatic imines to form 3-pyrrolines was developed. The presence of a substituent in the allylic compound is crucial for this reaction. Without the substituent, (E)-dienylimines will be produced via the dimerization of the allylic compounds.

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