4.8 Article

Chromofluorescent indicator for intracellular Zn2+/Hg2+ dynamic exchange

Journal

ORGANIC LETTERS
Volume 10, Issue 17, Pages 3801-3804

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol801482n

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Funding

  1. SRC [R11-2005-008-02001-0(2008)]
  2. KRF [KRF-2008-C00426]

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The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ-Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg2+. This results in the concomitant export of Hg2+ from the cells, showing that NABO can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.

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