4.8 Article

One-Pot Tandem Decarboxylative Allylation-Heck Cyclization of Allyl Diphenylglycinate Imines: Rapid Access to Polyfunctionalized 1-Aminoindanes

Journal

ORGANIC LETTERS
Volume 10, Issue 22, Pages 5131-5134

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol801986m

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Funding

  1. Kate Miller Jeffress Memorial Trust (J-808)
  2. UVA Bass Scholarship for Summer Undergraduate Research

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1-Aminoindanes are generated from allyl diphenylglycinate imines employing a one-pot palladium-catalyzed decarboxylative allylation-Heck cyclization cascade. Variation of both the aryl and allyl moieties leads to a diverse range of polycyclic imines, amenable to the synthesis of natural products and other biologically relevant small molecules.

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