Journal
ORGANIC LETTERS
Volume 10, Issue 20, Pages 4573-4576Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol801812a
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Funding
- National Natural Science Foundation of China [20532050, 20632060]
- Chinese Academy of Sciences
- Major Basic Research Development Program of China [2006CB806106]
- Science and Technology Commission of Shanghai Municipality
- Merck Research Laboratories
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A convenient and efficient synthesis of alpha-aryl nitriles was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%.
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