Journal
ORGANIC LETTERS
Volume 10, Issue 17, Pages 3729-3732Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol801230k
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Funding
- MEXT [KAKENHI, Houga 20655026]
- JST [PRESTO]
- Kurata Memorial Foundation
- JSPS
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A new triazole-linked analogue of DNA ((TL)DNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA.
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