Journal
ORGANIC LETTERS
Volume 10, Issue 20, Pages 4637-4640Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol801935r
Keywords
-
Categories
Funding
- Swedish Research Council
Ask authors/readers for more resources
A general and efficient method for the microwave-assisted formation of the C-P bond was developed. Using a prevalent palladium catalyst, Pd(PPh3)(4), a quantitative cross-coupling of various H-phosphonate diesters with aryl and vinyl halides was achieved in less than 10 min. The reactions occurred with retention of configuration at the phosphorus center and in the vinyl moiety. Using this protocol, several C-phosphonates, including those bearing nucleoside and cholesteryl moieties, were prepared in high yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available