4.8 Article

Functionalized Analogues of an Unnatural Amino Acid that Mimics a Tripeptide β-Strand

Journal

ORGANIC LETTERS
Volume 10, Issue 22, Pages 5293-5296

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol8021897

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Funding

  1. National Institutes of Health [GM-49076]

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This paper introduces polar and hydrophobic variants of the unnatural amino acid Hao, which mimics the hydrogen-bonding functionality of one edge of a beta-strand. In these variants, the methyl side chain of Hao is replaced with acidic, basic, and hydrophobic groups. These modifications can impart improved solubility and additional side-chain interactions to peptides containing Hao.

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