Journal
ORGANIC LETTERS
Volume 10, Issue 22, Pages 5111-5114Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol801911f
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Funding
- Seattle University
- NSF [0618784]
- Research Corporation [CC6444, 7292]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0618784] Funding Source: National Science Foundation
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Domino reactions were designed to allow the byproduct of an upstream reaction to be internally recycled to catalyze a downstream reaction in a one-pot tandem sequence. Nitroarene reduction by In(0) generates an amine and In(III) byproducts. Addition of aldehyde followed by Danishefsky's diene or silyl ketene acetal provides access to dihydropyridin-4-ones or,beta-amino esters, respectively, in yields that are comparable or superior to the reported stepwise reactions.
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