Journal
ORGANIC LETTERS
Volume 10, Issue 14, Pages 2997-3000Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol800932w
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Funding
- NCRR NIH HHS [S10 RR013866, 1-S10-RR13866] Funding Source: Medline
- NIAID NIH HHS [R01 AI055258, R01 AI055258-05A2] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008505] Funding Source: Medline
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The binding of a polymeric ligand to a cell surface receptor can promote its internalization. Methods to track and visualize multivalent ligands within a cell can give rise to new therapeutic strategies and illuminate signaling processes. We have used the features of the ring-opening metathesis polymerization (ROMP) to develop a general strategy for synthesizing multivalent ligands equipped with a latent fluorophore. The utility of ligands of this type is highlighted by visualizing multivalent antigen internalization in live B cells.
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