4.8 Article

Diastereoselective Palladium-Catalyzed α-Arylation of 4-Substituted Cyclohexyl Esters

Journal

ORGANIC LETTERS
Volume 10, Issue 22, Pages 5251-5254

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol8021758

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A diastereoselective palladium-catalyzed arylation of 4-substituted cyclohexyl esters has been developed. The reaction proceeds at room temperature in the presence of [(t-Bu(3)P)PdBr](2) providing products in up to 37:1 dr.

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