Journal
ORGANIC LETTERS
Volume 10, Issue 24, Pages 5501-5504Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8019132
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Funding
- National Institutes of Health (National Cancer Institute) [CA-19033]
- American Cancer Society
- National Fisheries Institute [PF-03-005-01-CDD]
- Japanese Society for the Promotion of Science
- University of Pennsylvania
- National Science Foundation [0131132]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0131132] Funding Source: National Science Foundation
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A convergent synthesis of (-)-2-epi-peloruside A has been achieved. Highlights include implementation of multicomponent type I anion relay chemistry (ARC) to unite 2-TBS-1,3-dithiane with two epoxides to construct the eastern hemisphere, a late-stage dithiane union to secure the complete, fully functionalized carbon backbone, and Yamaguchi macrolactonization, which led to (-)-2-epi-peloruside A via an unexpected epimerization at C(2).
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