Journal
ORGANIC LETTERS
Volume 10, Issue 21, Pages 4903-4906Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol801991m
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- Natural Sciences and Engineering Research Council of Canada (NSERC)
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A wide variety of substituted isoquinolin-1(2H)-ones were synthesized in reasonable to good yields by the palladium-catalyzed cyclization of diethyl(2-iodoaryl)malonates with imidoyl chlorides and carbon monoxide in tetrahydrofuran. A palladium-catalyzed carbonylation-decarboxylation process may be involved in the one-step synthesis of the isoquinolin-1(2H)-ones.
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