4.8 Article

Tin-Free Enantioselective Radical Reactions Using Silanes

Journal

ORGANIC LETTERS
Volume 10, Issue 23, Pages 5349-5352

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol802154d

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Funding

  1. NIH [GM-54656]

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Readily available hexyl silane is an excellent choice as a H-atom donor and a chain carrier in Lewis acid mediated enantioselective radical reactions. Conjugate radical additions to alpha,beta-unsaturated imides at room temperature proceed in good yields and excellent enantioselectivities.

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