Journal
ORGANIC LETTERS
Volume 10, Issue 17, Pages 3661-3663Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8012588
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Funding
- Canada Research Chair (Tier 1)
- NSERC
- McGill University
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An efficient method was developed for arylation of sp(3) C-H bonds using copper bromide as catalyst in absence of directing group with arylboronic acids. The oxidative arylation provides easy access to biologically active tetrahydroisoquinoline derivatives and can either use peroxide or molecular oxygen as oxidant.
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