Journal
ORGANIC LETTERS
Volume 10, Issue 24, Pages 5569-5572Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8021808
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Funding
- Alfred Werner Assistant Professorship
- SNF
- UZH
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N-Heterocyclic carbene ligands derived from C-2-symmetric diamines with naphthyl side chains are introduced as chiral monodentate ligands, and their palladium complexes (NHC)Pd(cin)CI are prepared. These compounds exist as a mixture of diastereomers, and the palladium complexes can be successfully separated and their absolute stereochemistry assigned. When used in the asymmetric intramolecular alpha-arylation of amides, oxindoles with quaternary carbon centers can be obtained in high yield and selectivity when correctly matching the chirality of the NHC complexes.
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