Journal
ORGANIC LETTERS
Volume 10, Issue 22, Pages 5155-5158Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8020989
Keywords
-
Categories
Funding
- Intramural Research Program of the NIH
- National Cancer Institute
- National Cancer Institute [N01-CO-12400]
Ask authors/readers for more resources
Although O-2-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished anti pro I iterative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
