Stereo- and regiospecific Cu-catalyzed, cross-coupling reaction of vinyl iodides and thiols: A very mild and general route for the synthesis of vinyl sulfides

A mild and efficient method for the copper-catalyzed formation of vinylic carbon-sulfur bonds has been developed. The desired vinyl sulfides are obtained in good to excellent yields, with full retention of stereochemistry. This method is particularly noteworthy given its mild reaction conditions, simplicity, and generality, as well as low cost of the catalyst system.