Journal
ORGANIC LETTERS
Volume 10, Issue 24, Pages 5505-5508Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol8020644
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Funding
- NIH, National Cancer Institute [CA44848, CA 52955]
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Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 mu M for marineosin A) and selective activities in diverse cancer cell types.
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