Direct catalytic asymmetric Mannich-type reaction of β-keto phosphonate using a dinuclear Ni2-Schiff base complex

Direct catalytic asymmetric Mannich-type reactions beta-keto phosphonates are described. A homodinuclear Ni-2-Schiff base complex promoted the reaction at 0 degrees C, giving beta-amino phosphonates in up to 90% yield, 20:1 dr, and 99% ee. Control experiments suggested that two Ni metals are important for achieving high yield and stereoselectivity.