Journal
ORGANIC LETTERS
Volume 10, Issue 8, Pages 1561-1564Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol702920e
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Funding
- NCRR NIH HHS [1U54 RR 022241-01, U54 RR022241] Funding Source: Medline
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A new fluorogenic cyanine dye was synthesized and found to have low fluorescence quantum yield in fluid solution and in the presence of double-stranded DNA but 80-fold enhanced fluorescence in viscous glycerol solution. An RNA aptamer selected for binding to the new dye exhibits K-d = 87 nM and 60-fold fluorescence enhancement. The dye-aptamer pair is a fluoromodule that can be incorporated into fluorescent sensors and labels.
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