4.8 Article

Proline-catalyzed direct inverse electron demand Diels-Alder reactions of ketones with 1,2,4,5-tetrazines

Journal

ORGANIC LETTERS
Volume 10, Issue 10, Pages 1923-1926

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol800417q

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An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.

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