4.8 Article

Ir-catalyzed regio- and enantioselective Friedel-Crafts-type allylic alkylation of indoles

Journal

ORGANIC LETTERS
Volume 10, Issue 9, Pages 1815-1818

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol800409d

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Highly regio- and enantioselective Ir-catalyzed Friedel-Crafts type allylic alkylation of indoles have been realized using [Ir(COD)Cl](2)/ phosphoramidite ligand 1a, affording the branched products with up to > 97/3 branched-linear ratio and 92% ee.

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